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Civil
Status
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39 years
old,
Married, 2 children, french citizenship
Address : 127 avenue Jean-Baptits Clément
F-92100 Boulogne-Billancourt
France
Phone: +33 (0)9 54 75 70 90
Skype : alexisbemelmans
E-mail |
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Education
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1999
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PhD in Molecular and Cellular Pharmacology,
University Paris VI.
Obtained with the highest distinction.
Certificate
(pdf file, 376 Ko)
Thesis dissertation
(in french) (pdf file, 1.9 Mo) |
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1994
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Postgraduate certificate in Molecular and
Cellular Pharmacology (Diplôme
d'Études Approfondies,
University Paris VI, "good" distinction). |
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1992
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Master's
degree in Cellular Biology and Physiology (University Paris VI). |
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1991
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Bachelor
in Science's degree in Cellular Biology and
Physiology (University Paris VI, "good" distinction). |
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2000
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Competence certificate
for animal experimentation (University
of Marseille). |
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2002
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Supplementary
competence certificate in animal surgery
(University of Marseille). |
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2004
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Swiss
certificate for animal experimentation (CHUV, Lausanne). |
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Work
Experience
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Since
2007:
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Project Manager, Fovea
Pharmaceuticals S.A., Paris, France.
www.fovea-pharma.com
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2004-07:
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Researcher in the Unit of Gene Therapy and
Stem Cells Biology, Jules-Gonin Eye Hospital, Lausanne
Switzerland. In charge of the gene therapy projects for Leber
congenital amaurosis and ocular neovascularizations. Supervision of the
work of 2 technicians and 1 PhD student. |
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1999-2003:
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Project leader "Business Development",
for BioVectys SA, a biotech company dedicated to the treatment of
neurological diseases by gene therapy.
* Writing up of the
business plan and of grant applications (which were granted by ANVAR
(French agency for research valorisation) in 2000, by French research
ministry in 2000 and 2001, by Association Retina France in 2002 and
2003.
* Setting up of a network with academic partners for a
project of gene therapy for retinal diseases.
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1994-99:
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PhD in a French academic lab, molecular
genetic of neurotransmission (CNRS) headed by Dr J Mallet (la
Pitié-Salpêtrière Hospital, Paris). Subject:
neuroprotective gene transfer in in vitro and in vivo models of
Huntington’s disease. |
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Linguistic
Skills
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French : mother tongue.
Very good writing (research project, activity report, etc..) as well as
oral skills.
English: fluent. Good
writing (scientific articles, patents, research project) and oral
skills.
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Technical
Skills
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Molecular Biology (plasmid
contruction, production of viral vector, quantitative pcr,
etc...).
Cell
Biology (cell line and primary culture of neural cells, flow
cytometry).
In Vivo Experimentation (stereotaxic
surgery, eye injections, behavioural tests,
electroretinogram recordings, pupil light reflex recordings, functional
testing of rodents models of neurological and retinal diseases.
Histology (cryostat
and paraffin sectioning, immunostaining, in situ hybridization,
morphometric analysis, confocal microscopy).
Computing (Windows
and Mac OS, Microsoft Office, Adobe Photoshop, internet ressources
for molecular biology, statistical analysis, etc...).
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Publications
List
(PubMed)
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- Bemelmans A.-P., Kostic C.,
Cachafeiro M., Crippa S.V., Wanner D., Tekaya M., Wenzel A.,
Arsenijevic Y. (2008) Lentiviral gene transfer-mediated cone
vision restoration in RPE65 knockout mice. Advances in
Experimental Medecine and Biology,
613:89-95
- Escartin C., Boyer F., Bemelmans A.-P., Hantraye
P., Broullet E. (2007) IGF-1 exacerbates the neurotoxicity of the
mitochondrial inhibitor 3NP in rats. Neuroscience
Letters, 425:167-172
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Bemelmans
A.-P.,
Kostic C., Hornfeld D., Jaquet M., Crippa S.V., Hauswirth W.W., Lem J.,
Wang Z., Schorderet D.E., Munier F.L., Wenzel A., Arsenijevic Y. (2006)
Lentiviral vectors containing a retinal pigment epithelium specific
promoter for leber congenital amaurosis gene therapy. Advances in
Experimental Medicine and Biology, 572: 247-253
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Molles B.E., Maskos U., Pons S., Besson M., Guiard
P.,
Guilloux J.-P., Evrad A., Cormier A., Mameli-Engvall M., Cloez-Tayarani
I., Nakatani H., Dufour N., Bemelmans
A.-P.,
Mallet J., Cazala P., Gardier A.-M., David V., Faure P., Granon S.,
Changeux J.-P. (2006) Targeted in vivo expression of nicotinic
acetylcholine receptors in mouse brain using lentiviral expression
vectors. Journal of molecular neuroscience , 30: 105-106. Editor
site
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Bemelmans
A.-P.,
Kostic C., Crippa S.V., Hauswirth W.W., Lem J., Munier F.L., Seeliger
M.W., Wenzel A., Arsenijevic Y. (2006) Lentiviral-mediated
transfer of the
RPE65 cDNA rescues both survival and function of cone photoreceptors in
a mouse model of leber congenital amaurosis. PLoS Medicine, 3:
1892-1903. Editor
site(open access)
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Bemelmans
A.-P., Husson I.,
Mallet
J., Kosofsky B.E. and Gressens P. (2006) Viral-mediated gene transfer
of BDNF is neuroprotective in a mouse model of neonatal excitotoxic
challenge. Journal of Neuroscience Research, 83: 50-60. Editor
site
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Brizard M., Carcenac C., Bemelmans
A.-P., Feuerstein C., Mallet J., Savasta M. (2006) Functional
reinnervation from remaining DA terminals induced by GDNF lentivirus in
a rat model of early Parkinson's disease. Neurobiology of Disease, 21:
90-101. Editor
site
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Maskos U., Molles B.E., Pons S.,
Besson M., Guiard B.P., Guilloux J.P., Evrard A., Cazala P., Cormier
A., Mameli-Engvall M., Dufour N., Cloez-Tayarani I., Bemelmans A.-P.,
Mallet J., Gardier A.M., David V., Faure P., Granon S., Changeux J.P.
(2005) Nicotine reinforcement and cognition restored by targeted
expression of nicotinic receptors. Nature, 436: 103-7. Editor
site
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Bemelmans
A.-P., Bonnel S.,
Houhou
L., Dufour N., Nandrot E., Helmlinger D., Sarkis C., Abitbol M. and
Mallet J. (2005) Retinal cell type expression specificity of
HIV-1-derived gene transfer vectors upon subretinal injection in the
adult rat: influence of pseudotyping and promoter. Journal of Gene
Medicine, 7: 1367-1374. Editor
site
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Girard C, Bemelmans
A.-P., Dufour
N, Mallet J, Bachelin C, Nait-Oumesmar B, Baron-Van Evercooren A,
Lachapelle F. (2005) Grafts of brain-derived neurotrophic factor and
neurotrophin 3-transduced primate Schwann cells lead to functional
recovery of the demyelinated mouse spinal cord. Journal of
Neuroscience, 25: 7924-33. Editor
site (free of charge)
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Escartin C., Boyer F., Bemelmans
A.-P., Hantraye P. and Brouillet E. (2004) Insulin Growth
Factor-1
protects against excitotoxicity in the rat striatum, NeuroReport, 15:
2251-4
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Husson I., Rangon C.M.,
Lelièvre V., Bemelmans
A.-P., Sachs P., Mallet J., Kosofsky B.
E. and Gressens P. (2005) BDNF-induced white matter neuroprotection and
stage-dependant neuronal survival following a neonatal excitotoxic
challenge, Cerebral Cortex, 15: 250-61
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Bemelmans
A.-P., Horellou
P.,
Pradier L., Brunet I., Colin P., Mallet J. (1999) Brain-derived
neurotrophic factor-mediated protection of striatal neurons in an
excitotoxic rat model of Huntington's disease, as demonstrated by
adenoviral gene transfer. Hum Gene Ther, 10: 2987-97
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Barkats M., Bemelmans A.-P.,
Geoffroy M.-C., Robert J.-J., Loquet I., Horellou P., Revah F., Mallet
J. (1996) An adenovirus encoding CuZnSOD protects cultured striatal
neurones against glutamate toxicity. Neuroreport, 7:497-501
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Recent
Oral
Presentations
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- Bemelmans A.-P.,
Kostic C., Hornfeld D., TekayaM., Crippa S.V., Hauswirth W.W., Lem J.,
Seeliger M., Wenzel A., Arsenijevic Y. Rescue of Cone Photoreceptors
after Lentiviral Gene Transfer of Rpe65 cDNA in Knockout Mouse Models
of Leber Congenital Amaurosis. 9th Annual Meeting of ASGT, Baltimore,
Maryland. May 31th-June 4th, 2006.
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Bemelmans A.-P., Wenzel A., Afanasieva T., Kostic
C., Jaquet M., Munier
F.L., Arsenijevic Y. Neuroprotective properties of an Anti-VEGF
single-chain antibody administered by gene transfer in the mouse
retina. 13th Annual Congress of ESGT, Prague, Czech Republic. Oct
29th-Nov 1st, 2005.
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Bemelmans A.-P., Kostic C., Hornfeld D., Hauswirth
W.W., Lem J.,
Schorderet D.F., Munier F.L., Seeliger M., Wenzel A., Arsenijevic Y.
Transfert de gène par vecteur lentiviral de l'ADNc RPE65 dans
deux lignées de souris knockout modélisant l'amaurose
congénitale de Leber. 4ème congrès annuel de la
société francophone de thérapie cellulaire et
génique, Lyon, France. 28-29 juin 2005.
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